A new translocation, t(1;3) (p36;q21), in myelodysplastic disorders.
نویسندگان
چکیده
منابع مشابه
A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells.
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), which is frequently characterized by trilineage dysplasia, in particular dysmegakaryocytopoiesis, and poor prognosis. Previously, the breakpoint cluster region (BCR) at 3q21 was identified within a 60-kilobase (kb) region centromeric to the BCR of 3q21q26 syndrome ...
متن کاملt(1;3)(p36;p21): presentation of a patient with MDS/AML (M2) and review of the literature.
t(1;3)(p36;p21) is a recurrent reciprocal translocation found in a subset of myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML) characterized by trilineage dysplasia, especially dysmegakaryopoiesis and poor prognosis. In the literature, some authors have suggested that this recurrent translocation is closely associated with prior chemotherapy including alkylating agents in various ...
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t(1;3)(p36;p21) is a recurrent reciprocal translocation found in a subset of myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML) characterized by trilineage dysplasia, especially dysmegakaryopoiesis and poor prognosis. In the literature, some authors have suggested that this recurrent translocation is closely associated with prior chemotherapy including alkylating agents in various ...
متن کاملt(1;3)(p36;q21) in acute nonlymphocytic leukemia: a new cytogenetic-clinicopathologic association.
A number of specific chromosomal abnormalities have been associated with distinctive clinical and/or morphological subtypes of acute nonlymphocytic leukemia (ANLL) in recent years. We have studied three patients with ANLL and t(1;3)(p36;q21). Each had weakness as their major complaint, a moderately severe anemia and, for ANLL, a relatively high platelet count. All three demonstrated abnormaliti...
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8. Bboomfield CD, Garson OM, Volin L, Knuutila 5, de Ia Chapelle A: t(l;3)(p36;q2l) in acute nonlymphocytic leukemia: A new cytogenetic-clinicopathologic association. Blood 66:1409, 1985 9. Viguie F, Marie J-P, Poler F, Bernadou A: Three cases of preleukemic myelodysplastic disorders with the same translocation t(l;3). Cancer Genet Cytogenet 19:213, 1986 10. Atichartakarn V, Punyammalee B, Wong...
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عنوان ژورنال:
- Blood
دوره 64 2 شماره
صفحات -
تاریخ انتشار 1984